Nitrate → HCID 15435719, compound

HRID 1740779Notes

Reaction equation

HRID 1740779 reaction equation
S([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]1[CH:24]=[N:25][C:26]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)=[CH:27][CH:28]=1)=[O:22])(C)(=O)=O.[N+:36]([O-])([O-:38])=[O:37]>C1(C)C=CC=CC=1>[O:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]1[CH:24]=[N:25][C:26]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)=[CH:27][CH:28]=1)=[O:22])[N+:36]([O-:38])=[O:37]

Participants

4

Reactant 2

HCID 943NitrateHCID 21833155HCID 21833155, compound

Product 1

HCID 15435719HCID 15435719, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of N-(14-mesyloxytetradecyl)-6-(4-methyl-1-piperazinyl)pyridine-3-carboxamide in toluene was added Amberlyst A-26 (a nitrate form) and the mixture was heated under reflux for 3 hours. The ion-exchange resin was filtered off and the filtrate was distilled off. The residue thus obtained was chromatographed over a silica gel column to afford 0.85 g of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. filtrationThe ion-exchange resin was filtered off
  4. distillationthe filtrate was distilled off
  5. customThe residue thus obtained
  6. customwas chromatographed over a silica gel column

Sources & evidence

ORD record
ord-236f908341ed425895e752cb223030ab
Source dataset
uspto-grants-1999_10
Patent number
US05972943

Reaction notes

Loading…