反应详情

温度

50 °C

A mixture of 5.0 g of 2-chloro-4-(1-pyrazolyl)methylphenol (produced in Reference Production Example 2), 7.6 g of ethyl chloroacetate, 13.2 g of potassium carbonate and 100 ml of anhydrous dimethylformamide was heated at 50° C. under stirring for 5 hours, and then cooled to room temperature. The reaction mixture was poured into 500 ml of water, which was extracted twice with 50 ml of ethyl acetate. The organic layers were combined, washed with water, saturated aqueous ammonium chloride solution and then saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to give crude ethyl 2-chloro-4-(1-pyrazolyl)methylphenoxyacetate as an oil.

1. temperaturecooled to room temperature
2. extractionwas extracted twice with 50 ml of ethyl acetate
3. washwashed with water, saturated aqueous ammonium chloride solution
4. dry with materialsaturated sodium chloride solution, dried with anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure