反应详情

A mixture of 4-chloro-5-nitro-2-phenylpyrimidine (6.0 g), 2-amino-N,N-dipropylacetamide (6.0 g), triethylamine (5.2 g) and isopropanol (70 ml) is refluxed for six hours. The reaction mixture is concentrated under reduced pressure, and to the residue are added chloroform and water. The chloroform layer is collected, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform), and recrystallized from ethanol to give the desired compound (8.8 g), m.p. 142-143° C.

1. temperatureis refluxed for six hours
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. additionto the residue are added chloroform and water
4. customThe chloroform layer is collected
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue is purified by silica gel column chromatography (eluent; chloroform)
8. customrecrystallized from ethanol