Hydrochloric Acid → HCID 18546167, compound

HRID 1740921Notes

Reaction equation

CS(C)=O.[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[CH2:15][C:16]1[O:17][C:18]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH2:27][OH:28])=[CH:21][C:19]=2[N:20]=1.C(N(CC)CC)C.Cl>ClCCl>[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[CH2:15][C:16]1[O:17][C:18]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]=[O:28])=[CH:21][C:19]=2[N:20]=1

Participants

Conditions

Temperature: 0 °C

Procedure

Oxalyl chloride[(COCl)2 ] (0.88 g) was added dropwise to a solution of dimethyl sulfoxide (DMSO) (1.0 g) in dichloromethane (30 ml) at -30° C. To the mixture was added 3-[2-(2-naphthylmethyl)benzoxazol-5-yl]-propanol (2.0 g). The mixture was stirred for 30 minutes at the same temperature. To the mixture was added triethyl amine (3.19 g). The mixture was stirred for 30 minutes, warmed to 0° C. and poured into 2N HCl. The organic layer was separated, washed with water and dried over magnesium sulfate (MgSO4). The solvent was distilled off, and the residue was subjected to silica gel column chromatography. From the fractions eluted with ethyl acetate-hexane (1:2, v/v), 3-[2-(2-naphthylmethyl)benzoxazol-5-yl]propionaldehyde (1.54 g, 77%) was obtained. Recrystallization from ether-isopropyl ether gave colorless needles. Melting point: 81-82° C.

Workup

stirringThe mixture was stirred for 30 minutes
customThe organic layer was separated
washwashed with water
dry with materialdried over magnesium sulfate (MgSO4)
distillationThe solvent was distilled off
washFrom the fractions eluted with ethyl acetate-hexane (1:2

Sources & evidence

ORD record: ord-b1f86153f81a4087892a86dbdaee29d9
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972970

Reaction notes

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