Potassium Hydroxide → HCID 10219534, compound

HRID 1740975Notes

Reaction equation

HRID 1740975 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:9]=[C:8]([N:10]2C(C)=CC=C2C)[CH:7]=[C:6]([CH3:17])[CH:5]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:10][C:8]1[CH:7]=[C:6]([CH3:17])[CH:5]=[C:4]([CH2:3][CH2:2][NH2:1])[N:9]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 21834412HCID 21834412, compound

Product 1

HCID 10219534HCID 10219534, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

By analogy to Example 56, Step B, 6-(2-aminoethyl)-4-methyl-2-(2,5-dimethylpyrrol-1-yl)pyridine was treated with 4.6 equivalents of hydroxylamine hydrochloride and 3.2 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-6-(2-aminoethyl)-4-methylpyridine.

Sources & evidence

ORD record
ord-85e8a28d9f7247098a4885b97bf1aa96
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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