Potassium Hydroxide → 2-Amino-4-methyl-6-(2-phenylethyl)pyridine

HRID 1740987노트

반응식

HRID 1740987 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=[C:4]([N:16]2C(C)=CC=C2C)[CH:3]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:16][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 218344294-Methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(2-phenylethyl)pyridine

생성물 1

HCID 99207692-Amino-4-methyl-6-(2-phenylethyl)pyridine

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

By analogy to Example 56, Step B, 4-methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(2-phenylethyl)pyridine was treated with 4.6 equivalents of hydroxylamine hydrochloride and 2.8 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-4-methyl-6-(2-phenylethyl)pyridine as a colorless oil.

출처 및 근거

ORD 기록
ord-e4a03b5712e04e35898eadd280eebc6a
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05972975

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