Hydrochloric Acid → HCID 9834715, compound

HRID 1740989Notes

Reaction equation

HRID 1740989 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[CH:5]=[C:4]([CH3:16])[CH:3]=1.[ClH:17]>>[ClH:17].[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[C:4]([CH3:16])[CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21834433HCID 21834433, compound

Product 1

HCID 9834715HCID 9834715, compound

Procedure

A mixture of methyl 5-(6-amino-4-methyl-2-pyridinyl)pentanoate (119 mg, 0.536 mmol) in 10 mL of 2.0 N hydrochloric acid was refluxed for 3 h. After cooling to room temperature, the reaction was extracted with 2×10 mL of dichloromethane and the aqueous phase was concentrated in vacuo to give 134 mg of 5-(6-amino-4-methyl-2-pyridinyl)pentanoic acid hydrochloride as a pink solid.

Workup

  1. temperaturewas refluxed for 3 h
  2. extractionthe reaction was extracted with 2×10 mL of dichloromethane
  3. concentrationthe aqueous phase was concentrated in vacuo

Sources & evidence

ORD record
ord-6d39fa5ba2304f5eb8c5ec6fd3d06f16
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

Loading…