反应详情

2,3-Dihydro-1'-methylspiro[furo[2,3-f]indole-3,4'-piperidine] (D7, 0.056 g, 0.23 mmol) was stirred in acetic acid (5 ml) as sodium cyanoborohydride (0.044 g, 0.70 mmol) was added portionwise over 10 min. The solution was stirred for 2 h, diluted with water (20 ml), basified with saturated K2CO3 solution, and extracted with ethyl acetate. The extract was dried (Na2SO4) and evaporated to give the title compound (0.030 g, 53%) as a white solid.

1. additionwas added portionwise over 10 min
2. extractionextracted with ethyl acetate
3. dry with materialThe extract was dried (Na2SO4)
4. customevaporated