Methylamine → HCID 70197996, compound

HRID 1741077Notes

Reaction equation

HRID 1741077 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[CH3:10].[CH3:11][NH2:12].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:11][NH2:12])=[CH:4][C:3]=1[CH3:10]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 11430Potassium CarbonateHCID 109215214-Bromo-3-methylbenzaldehyde

Product 1

HCID 70197996HCID 70197996, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Bromo-3-methylbenzaldehyde (D80, 3.7 g, 18.6 mmol) was treated with methylamine in ethanol (33%, 100 ml) followed by 4 Å molecular sieves and solid potassium carbonate (approx 4 g) and the mixture stirred for 72 hours. Solvent was removed in vacuo, the residue suspended in chloroform, and the solid removed by filtration. The filtrate was evaporated in vacuo to yield the title compound as a red liquid (3.15 g, 80%).

Workup

  1. customSolvent was removed in vacuo
  2. customthe solid removed by filtration
  3. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-11619aeb39c041f7bbb536bd39bf7c4b
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

Loading…