Sulfuric Acid → Creatine

HRID 1741181Notes

Reaction equation

[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].O.[O:7]=[C:8]([CH2:10][N:11]([C:13](=[NH:15])[NH2:14])[CH3:12])[OH:9]>>[O:7]=[C:8]([CH2:10][N:11]([C:13](=[NH:14])[NH2:15])[CH3:12])[OH:9].[S:1](=[O:3])(=[O:2])([OH:5])[OH:4]

Participants

Reactant 2

HCID 1118Sulfuric Acid2×

HCID 80116Creatine Monohydrate

Product 2

HCID 586Creatine

HCID 1118Sulfuric Acid

Procedure

In the preparation of the creatine acid sulfate salt, the concentration of the sulfuric acid solution is first determined, which is preferably between 31% and 35% sulfuric acid. Then the amount of creatine monohydrate is calculated to provide a molar ratio of creatine to sulfuric acid to be about 2.0:1.0. The amount of creatine monohydrate is then determined from the calculated amount of the anhydrous creatine. Creatine monohydrate is generally preferred since anhydrous creatine can be more easily converted to creatinine than the monohydrate.

Sources & evidence

ORD record: ord-7cb46bcf70694af9befb609fe671030c
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05973005

Reaction notes

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