Hydrochloric Acid → HCID 131721416, compound

HRID 1741208Notes

Reaction equation

HRID 1741208 reaction equation
[CH2:1]([S:6]([C:9]1[CH:10]=[CH:11][C:12]2[C:16]([C:17]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:21][CH:20]=3)=[O:18])=[C:15]([C:34]3[CH:39]=[CH:38][C:37]([S:40]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])(=[O:42])=[O:41])=[CH:36][CH:35]=3)[S:14][C:13]=2[CH:48]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5].[ClH:49]>C(OCC)(=O)C>[ClH:49].[CH2:1]([S:6]([C:9]1[CH:10]=[CH:11][C:12]2[C:16]([C:17]([C:19]3[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:23][CH:24]=3)=[O:18])=[C:15]([C:34]3[CH:39]=[CH:38][C:37]([S:40]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])(=[O:42])=[O:41])=[CH:36][CH:35]=3)[S:14][C:13]=2[CH:48]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18357250HCID 18357250, compound

Product 1

HCID 131721416HCID 131721416, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[6-(n-Pentylsulfonoyl)-2-[4-(n-pentylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone (3.7 g) was dissolved in 25 ml of ethyl acetate and a solution of hydrochloric acid saturated diethyl ether was added. A precipitate formed and the liquid decanted off. The gummy solid was triturated with diethyl ether and dried in vacuo at room temperature to afford 2.12 g of the title compound as a white amorphous and hygroscopic solid.

Workup

  1. customA precipitate formed
  2. customthe liquid decanted off
  3. customThe gummy solid was triturated with diethyl ether
  4. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-6504c38db9af45f48b4735925f9ccd59
Source dataset
uspto-grants-1999_10
Patent number
US05972888

Reaction notes

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