Diethylformamide → 4,5,7-Trichloroquinoline

HRID 1741260Notes

Reaction equation

HRID 1741260 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[C:4](O)=[CH:5][CH:6]=[N:7]2.S(Cl)([Cl:16])=O.C(N(CC)C=O)C>CN(C)C=O>[Cl:16][C:4]1[C:3]2[C:8](=[CH:9][C:10]([Cl:12])=[CH:11][C:2]=2[Cl:1])[N:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 12051DiethylformamideHCID 24386Thionyl ChlorideHCID 178418458HCID 178418458, compound

Product 1

HCID 6158354,5,7-Trichloroquinoline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

reacting 5,7-dichloro-4-hydoxyquinoline with thionyl chloride in the presence of N,N-dimethylformamide or N,N-diethylformamide to obtain 4,5,7-trichloroquinoline,

Sources & evidence

ORD record
ord-632837123a594dd9a3d655f2584c17b1
Source dataset
uspto-grants-1999_10
Patent number
US05973153

Reaction notes

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