反应详情

To a suspension of lithium aluminum hydride (2.86 g, 74.4 mmol) in THF (300 ml) at 0°, is added methyl 4'-fluoro-4-biphenylyl-carboxylate (8.67 g, 37.7 mmol) as a solution in THF (100 ml). The resulting mixture is stirred for 1 hour and subsequently allowed to warm to room temperature. The reaction mixture is chilled to 0° and 2N HCl (100 ml) is slowly added. The resulting mixture then is extracted with Et2O (2×150 ml). The combined organic portions are washed with saturated NaHCO3 solution (400 ml), saturated NaCl solution (400 ml), dried over MgSO4 and concentrated in vacuo, to yield 4'-fluoro-4-biphenylyl-methanol as a white solid.

1. temperatureThe reaction mixture is chilled to 0°
2. extractionThe resulting mixture then is extracted with Et2O (2×150 ml)
3. washThe combined organic portions are washed with saturated NaHCO3 solution (400 ml), saturated NaCl solution (400 ml)
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo