反应详情

To a solution of chlorotrimethylsilane (16.3 g) and triethylamine (30.3 g) in N,N-dimethylformamide (50 ml) was added 4'-isobutylacetophenone (22.0 g). The yellow solid was immediately filtered off, and the filtrate was refluxed for 20 hours. The mixture was cooled, diluted with hexane, and washed with cooled aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate and concentrated. The residue was distilled under reduced pressure to give 4-isobutyl-α-trimethylsilyloxystyrene (9.0 g) as an oil.

1. filtrationThe yellow solid was immediately filtered off
2. temperaturethe filtrate was refluxed for 20 hours
3. temperatureThe mixture was cooled
4. additiondiluted with hexane
5. washwashed with cooled aqueous sodium bicarbonate
6. dry with materialThe organic layer was dried over magnesium sulfate
7. concentrationconcentrated
8. distillationThe residue was distilled under reduced pressure