反应详情

A mixture of ethyl 4-[1-(3-aminobenzoyl)indolizin-3-yl]butyrate (175 mg), 1-bromohexyl-4-isobutylbenzene (177 mg) and diisopropylethylamine (194 mg) in dichloromethane (3 ml) was refluxed for 20 hours. The reaction mixture was poured into a mixture of ethyl acetate and water. The organic layer was separated and washed with water and brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel column eluting with n-hexane and ethyl acetate (3:1) to give ethyl 4-[1-[3-[1-(4-isobutylphenyl)hexylamino]benzoyl]indolizin-3-yl]butyrate (170 mg) as an oil.

1. temperaturewas refluxed for 20 hours
2. customThe organic layer was separated
3. washwashed with water and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe residue was chromatographed on silica gel column
7. washeluting with n-hexane and ethyl acetate (3:1)