Ammonium Chloride → HCID 22392078, compound

HRID 1742002Notes

Reaction equation

HRID 1742002 reaction equation
[C:1]([Mg]Br)#[CH:2].[F:5][C:6]([F:15])([F:14])[C:7]1[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=1.[Cl-].[NH4+]>O1CCCC1>[C:1]([CH:12]([C:10]1[N:11]=[C:7]([C:6]([F:5])([F:14])[F:15])[S:8][CH:9]=1)[OH:13])#[CH:2]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 200867172-(Trifluoromethyl)-1,3-thiazole-4-carbaldehydeHCID 178418486HCID 178418486, compound

Product 1

HCID 22392078HCID 22392078, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

11 cm3 of a molar solution of ethynyl magnesium bromide is added to a solution of tetrahydrofuran containing 2 g of 2-(trifluoromethyl) 4-thiazolecarboxaldehyde. The reaction mixture is kept under agitation for 30 minutes at 20°/25° C. then it is poured into an ammonium chloride solution. Extraction is carried out with methylene chloride, the extracts are dried, filtered and brought to dryness. 2.1 g of desired product is obtained.

Workup

  1. extractionExtraction
  2. customthe extracts are dried
  3. filtrationfiltered

Sources & evidence

ORD record
ord-18d0c6a4a2fd41a38f09f4a1f839a06a
Source dataset
uspto-grants-1994_08
Patent number
US05336670

Reaction notes

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