1H-Pyrazol-3-amine, 5-methyl- → HCID 85412723, compound

HRID 1742067Notes

Reaction equation

HRID 1742067 reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([NH2:7])[CH:3]=1.[C:8]1([CH2:14][CH2:15][C:16](Cl)=[N:17][OH:18])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>[N+](C)([O-])=O>[NH2:7][C:4]1[N:5]([C:16](=[N:17][OH:18])[CH2:15][CH2:14][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:6]=[C:2]([CH3:1])[CH:3]=1

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 73083080HCID 73083080, compound

Product 1

HCID 85412723HCID 85412723, compoundYield 57.9%

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

Analogous to example 1, synthesis step 1, using 5.65 g (0.058 mol) of 3(5)-amino-5(3)-methyl-pyrazole and 10.6 g (0.058 mol) of 3-phenyl-propanehydroximoyl chloride. The oil obtained as raw product is dissolved in nitromethane in the cold and made to crystallise by scratching the side of the container. 8.2 g (57%) of 5-amino-3-methyl-1-(3-phenyl-propanehydroximoyl)-pyrazole with a m. pt. of 138°-140° C. are obtained.

Workup

  1. customAnalogous to example 1, synthesis step 1
  2. customThe oil obtained as raw product
  3. customto crystallise

Sources & evidence

ORD record
ord-65adf0b10d69438d8c8f0ba22bc4733b
Source dataset
uspto-grants-1994_08
Patent number
US05336780

Reaction notes

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