Hydroxyphenylacetic acid → Ethyl 4-hydroxyphenylacetate

HRID 1742159Notes

Reaction equation

HRID 1742159 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 127Hydroxyphenylacetic acidHCID 702EthanolHCID 1118Sulfuric Acid

Product 1

HCID 28310Ethyl 4-hydroxyphenylacetate

Procedure

4-Hydroxyphenylacetic acid (50.0 g) is dissolved in ethanol (400 ml) and thereto is added conc. sulfuric acid (0.5 ml). The mixture is refluxed with stirring, and ethanol is distilled off to give ethyl 4-hydroxyphenylacetate (60 g).

Workup

  1. temperatureThe mixture is refluxed
  2. distillationethanol is distilled off

Sources & evidence

ORD record
ord-c7b5678d9bf1405bba98f3a324811eb9
Source dataset
uspto-grants-1994_08
Patent number
US05338482

Reaction notes

Loading…