反应详情

Ethyl 3-aminopropionate hydrochloride (2.00 g, 13.0 mmol) was dissolved in dichloromethane (40 ml), and benzyl chloroformate (2.00 ml, 14.1 mmol) was added. With cooling with ice, triethylamine (4.00 ml, 28.9 mmol) was added, followed by stirring at room temperature for 15 hours, then the reaction, liquid was concentrated. Ethyl acetate and water were added, the organic layer was collected, and dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, the resulting residue was purified by silica gel column chromatography (dichloromethane to dichloromethane:methanol=70:1) to obtain a pale yellow oil (3.26 g, quant).

1. additionwas added
2. customthe reaction, liquid
3. concentrationwas concentrated
4. additionEthyl acetate and water were added
5. customthe organic layer was collected
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was evaporated away under reduced pressure
8. customthe resulting residue was purified by silica gel column chromatography (dichloromethane to dichloromethane:methanol=70:1)
9. customto obtain a pale yellow oil (3.26 g, quant)