Methylamine → 2-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

HRID 1742921Notes

Reaction equation

HRID 1742921 reaction equation
[CH3:1][NH2:2].[NH2:3][C:4]1[N:9]=[C:8](F)[N:7]=[C:6]([O:11][C:12]([F:15])([F:14])[F:13])[N:5]=1>O1CCCC1>[NH2:3][C:4]1[N:9]=[C:8]([NH:2][CH3:1])[N:7]=[C:6]([O:11][C:12]([F:15])([F:14])[F:13])[N:5]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103972-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
22 °C

Procedure

3.5 g (0.111 mol) of methylamine were passed over the course of 20 minutes into a stirred solution of 11 g (0.055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 150 ml of tetrahydrofuran at 0° C. The mixture was stirred at 0° C. for one hour and at 22° C. overnight. It was then concentrated under reduced pressure, stirred with water and dried. 10.8 g (93.1% of theory) of the title compound of melting point 155°-157° C. (decomposition) were obtained.

Workup

  1. concentrationIt was then concentrated under reduced pressure
  2. stirringstirred with water
  3. customdried

Sources & evidence

ORD record
ord-b906037265134a92aae0824ebd73a7ea
Source dataset
uspto-grants-1994_08
Patent number
US05342939

Reaction notes

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