1-Chloromethylnaphthalene → HCID 22237306, compound

HRID 1743081Notes

Reaction equation

HRID 1743081 reaction equation
[Cl:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[CH3:13][C:14]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:17])=[CH2:15].COC1C=CC(O)=CC=1>CC(C)=O>[Cl:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[CH3:24][N:22]([CH3:23])[CH2:21][CH2:20][CH2:19][NH:18][C:16](=[O:17])[C:14]([CH3:15])=[CH2:13]

Participants

5

Reactant 3

HCID 68451-ChloromethylnaphthaleneHCID 90154-MethoxyphenolHCID 78882N-(3-(Dimethylamino)propyl)methacrylamide

Product 1

HCID 22237306HCID 22237306, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A 100 ml flask is charged with 1-chloromethyl naphthalene (7.06 g, 40 mmol), DMAPMA (7.48 g, 44 mmol), MEHQ (0.1 g) and acetone (50 ml). The mixture is heated at reflux for 4 hours. The solvent is then removed under vacuum and the resulting gooey DMAPMA.MNQ solidifies upon standing at room temperature.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 4 hours
  3. customThe solvent is then removed under vacuum
  4. customupon standing at room temperature

Sources & evidence

ORD record
ord-350849315e6a42c18d12b80387a79d08
Source dataset
uspto-grants-2006_03
Patent number
US07008618B1

Reaction notes

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