Ammonia → HCID 67137526, compound

HRID 1743240Notes

Reaction equation

HRID 1743240 reaction equation
[CH2:1]([C@:8]1([NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:15](=[O:16])[N:14]2[C@@H:10]([S:11][CH2:12][C@H:13]2[C:17]([O:19]C)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:29].COC(C)(C)C>CO>[CH2:1]([C@:8]1([NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:26])[CH3:27])=[O:23])[C:15](=[O:16])[N:14]2[C@@H:10]([S:11][CH2:12][C@H:13]2[C:17]([NH2:29])=[O:19])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 15413tert-Butyl methyl etherHCID 69795109HCID 69795109, compound

Product 1

HCID 67137526HCID 67137526, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 170 mg of methyl (3R,6R,7aS)-6-benzyl-6-tert-butoxycarbonylamino-5-oxohexahydropyrrolo[2,1-b]thiazole-3-carboxylate and 10 ml of a 7N NH3 solution in methanol is left to stand at room temperature overnight. The volatile constituents are stripped off in vacuo, and the residue is stirred with tert-butyl methyl ether, and the solid is filtered off with suction and dried in vacuo at 40° C.

Workup

  1. waitis left
  2. filtrationthe solid is filtered off with suction
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-7fba5c9c4f804c77b22bade6a4e24e95
Source dataset
uspto-grants-2006_03
Patent number
US07008957B2

Reaction notes

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