Trifluoroacetic acid → HCID 11245132, compound

HRID 1743252Notes

Reaction equation

HRID 1743252 reaction equation
[C:1]([C@@H:3]1[CH2:7][S:6][C@H:5]2[CH2:8][C@:9]([NH:16]C(=O)OC(C)(C)C)([CH2:12][CH:13]([CH3:15])[CH3:14])[C:10](=[O:11])[N:4]12)#[N:2].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>C1(SC)C=CC=CC=1>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[NH2:16][C@@:9]1([CH2:12][CH:13]([CH3:15])[CH3:14])[C:10](=[O:11])[N:4]2[C@@H:5]([S:6][CH2:7][C@H:3]2[C:1]#[N:2])[CH2:8]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 91582719HCID 91582719, compound

Product 1

HCID 11245132HCID 11245132, compound

Reagents, catalysts & solvents 1

HCID 7520ThioanisoleSolvent

Procedure

53 mg of tert-butyl (3R,6R,7aS)-(3-cyano-6-isobutyl-5-oxohexahydropyrrolo[2,1-b]thiazol-6-yl)-carbamate were reacted with 3 ml of trifluoroacetic acid and 600 μl of thioanisole at 0° C. for 30 min. The solvents were then removed in vacuo, and the residue was stirred in diethyl ether, filtered off with suction and dried.

Workup

  1. customThe solvents were then removed in vacuo
  2. filtrationfiltered off with suction
  3. customdried

Sources & evidence

ORD record
ord-c2dfd9a2d716465cb04392f1f9e6dbec
Source dataset
uspto-grants-2006_03
Patent number
US07008957B2

Reaction notes

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