反应详情

10.5 g of 4-piperidinylmethanol were dissolved in 170 ml of THF. 25.8 g of 2-(trimethylsilyl)ethyl 4-nitrophenyl carbonate and 15.9 ml of N,N-diisopropylethylamine were successively added thereto. The mixture was stirred at room temperature for 1 h and then the solvent was removed in vacuo. The residue was taken up in 400 ml of ethyl acetate and washed once with 300 ml of 0.5 N HCl and twice with 250 ml of 1 N NaOH each time. The organic phase was dried with MgSO4, the solvent was removed in vacuo, and the residue was purified by chromatography on silica gel.

1. customthe solvent was removed in vacuo
2. washwashed once with 300 ml of 0.5 N HCl and twice with 250 ml of 1 N NaOH each time
3. dry with materialThe organic phase was dried with MgSO4
4. customthe solvent was removed in vacuo
5. customthe residue was purified by chromatography on silica gel