Triethylamine → 2-Propenoic acid, 3-phenyl-

HRID 1743281Notes

Reaction equation

HRID 1743281 reaction equation
Br[C@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:3]([OH:5])(=[O:4])[CH:2]=[CH:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 11746403(R)-2-Bromo-3-phenylpropionic acid

Product 1

HCID 87842-Propenoic acid, 3-phenyl-

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5 g of (2R)-2-bromo-3-phenylpropionic acid (HPLC: 92.5%) were treated at room temperature with 2.7 ml of triethylamine in 20 ml of toluene. After a stirring time of about 150 minutes, no precipitation of the product was to be observed. An HPLC analysis of the solution showed that the (2R)-2-bromo-3-phenylpropionic acid had reacted completely to give cinnamic acid.

Workup

  1. customAfter a stirring time of about 150 minutes, no precipitation of the product
  2. customhad reacted completely

Sources & evidence

ORD record
ord-e20e19ee1df640f9bca54e9b64bb0fda
Source dataset
uspto-grants-2006_03
Patent number
US07009047B2

Reaction notes

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