Sodium hydride → HCID 22234977, compound

HRID 1743539Notes

Reaction equation

HRID 1743539 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([Cl:18])[C:3]=1[CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].[H-].[Na+].Br[CH2:22][CH2:23][C:24]([F:27])([F:26])[F:25]>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[CH:11]=[C:10]([Cl:18])[C:3]=1[CH2:4][C:5]([CH2:22][CH2:23][C:24]([F:27])([F:26])[F:25])([C:6]#[N:7])[C:8]#[N:9]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 22235073HCID 22235073, compound

Product 1

HCID 22234977HCID 22234977, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.30 g of (2,6-dichloro-4-(trifluoromethyl)benzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.20 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.21 g of 2-(2,6-dichloro-4-(trifluoromethyl)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (7)).

Sources & evidence

ORD record
ord-09b0c69a8c1e444c9c21fbb415714f7a
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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