Sodium hydride → HCID 22235017, compound

HRID 1743549Notes

Reaction equation

HRID 1743549 reaction equation
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[H-].[Na+].Br[CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22]>CN(C)C=O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C:9]([CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22])([C:10]#[N:11])[C:12]#[N:13])=[CH:14][CH:15]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 27641462-(4-nitrobenzyl)malononitrile

Product 1

HCID 22235017HCID 22235017, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 5.00 g of (4-nitrobenzyl)malononitrile, 60 ml of N,N-di-methylformamide, 1.10 g of sodium hydride (60% in oil), and 4.85 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.80 g of 2-(4-nitrobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (18)).

Sources & evidence

ORD record
ord-58355505172940e985c595020f0668eb
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

Loading…