Sodium hydride → HCID 22235043, compound

HRID 1743564Notes

Reaction equation

HRID 1743564 reaction equation
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Br)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[F:15][C:16]([F:25])([F:24])[CH2:17][CH2:18][CH:19]([C:22]#[N:23])[C:20]#[N:21]>CN(C)C=O>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][C:19]([CH2:18][CH2:17][C:16]([F:15])([F:24])[F:25])([C:20]#[N:21])[C:22]#[N:23])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzeneHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235043HCID 22235043, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.23 g of 4-t-butylbenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.14 g of 2-(4-t-butylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (33)).

Sources & evidence

ORD record
ord-0df5e8e8f7404ece80cfc35e466e98f2
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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