Sodium hydride → 2-(2-Chloro-4-(trifluoromethyl)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile

HRID 1743572Notes

Reaction equation

HRID 1743572 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH2:4]Br.[H-].[Na+].[F:16][C:17]([F:26])([F:25])[CH2:18][CH2:19][CH:20]([C:23]#[N:24])[C:21]#[N:22]>CN(C)C=O>[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH2:4][C:20]([CH2:19][CH2:18][C:17]([F:16])([F:25])[F:26])([C:21]#[N:22])[C:23]#[N:24]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 220585591-(Bromomethyl)-2-chloro-4-(trifluoromethyl)benzeneHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 222350752-(2-Chloro-4-(trifluoromethyl)benzyl)-2-(3,3,3-trifluoropropyl)malononitrileYield 39%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.10 g of 2-chloro-4-(trifluoromethyl)benzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and. 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.05 g of 2-(2-chloro-4-(trifluoromethyl)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (41)).

Sources & evidence

ORD record
ord-b1d09302d7df43a189353c4b8ede4fd0
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

Loading…