Potassium Carbonate → HCID 22235064, compound

HRID 1743573Notes

Reaction equation

HRID 1743573 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]([C:13]#[N:14])[C:11]#[N:12])[CH3:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:22][CH2:23][C:24]([F:27])([F:26])[F:25]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]([CH2:22][CH2:23][C:24]([F:27])([F:26])[F:25])([C:11]#[N:12])[C:13]#[N:14])[CH3:9])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 11687105HCID 11687105, compound

Product 1

HCID 22235064HCID 22235064, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 2.05 g of 2-(1-(4-chlorophenyl)ethyl)malononitrile, 10 ml of N,N-dimethylformamide, 1.38 g of potassium carbonate, and 1.77 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.49 g of 2-(1-(4-chlorophenyl)ethyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (42)).

Sources & evidence

ORD record
ord-ee4b4475b2ea4290b1d732077ba5caf2
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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