2-Fluoroethyl bromide → HCID 22234974, compound

HRID 1743576Notes

Reaction equation

HRID 1743576 reaction equation
[C:1]([C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1)#[N:2].[H-].[Na+].Br[CH2:18][CH2:19][F:20]>CN(C)C=O>[C:1]([C:3]1[CH:14]=[CH:13][C:6]([CH2:7][C:8]([CH2:18][CH2:19][F:20])([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 24758Sodium hydrideHCID 11286827HCID 11286827, compound

Product 1

HCID 22234974HCID 22234974, compoundYield 24.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.32 g of (4-cyanobenzyl)malononitrile, 7 ml of N,N-di-methylformamide, 0.12 g of sodium hydride (60% in oil), and 0.25 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.10 g of 2-(4-cyanobenzyl)-2-(2-fluoroethyl)malononitrile (the present compound (46)).

Sources & evidence

ORD record
ord-0d0cb4ff56b1449083192e06e175f81d
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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