2,4-Dichlorobenzyl chloride → HCID 22235070, compound

HRID 1743610Notes

Reaction equation

HRID 1743610 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH2:4]Cl.[H-].[Na+].[F:13][C:14]([F:23])([F:22])[CH2:15][CH2:16][CH:17]([C:20]#[N:21])[C:18]#[N:19]>CN(C)C=O>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH2:4][C:17]([CH2:16][CH2:15][C:14]([F:13])([F:22])[F:23])([C:18]#[N:19])[C:20]#[N:21]

Participants

5

Reactant 3

HCID 72122,4-Dichlorobenzyl chlorideHCID 24758Sodium hydrideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235070HCID 22235070, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.20 g of 2,4-dichlorobenzyl chloride, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.23 g of 2-(2,4-dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (83)).

Sources & evidence

ORD record
ord-2b57b2548c2b4fea9a52c9ef8e4372da
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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