p-Xylyl bromide → HCID 22235002, compound

HRID 1743611Notes

Reaction equation

HRID 1743611 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[H-].[Na+].[F:12][C:13]([F:22])([F:21])[CH2:14][CH2:15][CH:16]([C:19]#[N:20])[C:17]#[N:18]>CN(C)C=O>[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][C:16]([CH2:15][CH2:14][C:13]([F:12])([F:21])[F:22])([C:17]#[N:18])[C:19]#[N:20])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7721p-Xylyl bromideHCID 24758Sodium hydrideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235002HCID 22235002, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.19 g of 4-methylbenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.20 g of 2-(4-methylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (84)).

Sources & evidence

ORD record
ord-3e01c07b76a54fa28f4684194b6b7562
Source dataset
uspto-grants-2006_03
Patent number
US07011838B2

Reaction notes

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