Ammonia → HCID 22235510, compound

HRID 1743729Notes

Reaction equation

HRID 1743729 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1.[NH3:15]>C(O)(C)C>[NH2:15][CH2:3][CH:2]([OH:1])[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 222353954-[2-(Oxiran-2-yl)ethoxy]benzonitrile

Product 1

HCID 22235510HCID 22235510, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-[2-(2-Oxiranyl)ethoxy]benzonitrile (38.5 g, 204 mmol; from step (d) above) was mixed with NH3 (1200 mL, conc.) and isopropanol (450 mL). The mixture was stirred at r.t for 24 h. The solid (by-product) was filtered off and the solvents were evaporated, to give 39.1 g (93%) of sub-title compound.

Workup

  1. filtrationThe solid (by-product) was filtered off
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-d82a0e66b3e94ca48634b78a404a60f1
Source dataset
uspto-grants-2006_03
Patent number
US07012074B2

Reaction notes

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