反应详情

温度

70 °C

To a solution of methyl 2,6-bis[(2,2-dimethylpropanoyl)amino]nicotinate (EXAMPLE 1, Step 1, 186 g, 555 mmol) in anhydrous N,N-dimethylformamide (930 mL) was added a solution of N-chlorosuccinimide (81.5 g, 610 mmol) in anhydrous N,N-dimethylformamide (560 mL) dropwise from a dropping funnel (1 L) during the period of 2.5 h at 70° C. (internal temperature) under nitrogen atmosphere. The resulting pale yellow solution was stirred at 70° C. for 2 h and allowed to cool to room temperature. The reaction solution was quenched with a solution of 250 g of ammonium chloride and 100 g of sodium hydrogen sulfite in 3 L of water and extracted with a mixture of ethyl acetate and hexane (3 L, 3:1). After the layers were separated, the organic layer was washed with water (2 L), dried over sodium sulfite (300 g) and evaporated. The residual pale yellow solid was added isopropylether (1.4 L) and the resulting mixture was stirred at 60° C. for 2 h. After the mixture was cooled to room temperature, the mixture was filtered through paper filter, and the cake was washed with isopropylether (200 mL), dried under reduced pressure at room temperature to give (153.9 g, 416 mmol) of the title compound as a white solid.

1. temperatureto cool to room temperature
2. customThe reaction solution was quenched with a solution of 250 g of ammonium chloride and 100 g of sodium hydrogen sulfite in 3 L of water
3. extractionextracted with a mixture of ethyl acetate and hexane (3 L, 3:1)
4. customAfter the layers were separated
5. washthe organic layer was washed with water (2 L)
6. dry with materialdried over sodium sulfite (300 g)
7. customevaporated
8. additionThe residual pale yellow solid was added isopropylether (1.4 L)
9. stirringthe resulting mixture was stirred at 60° C. for 2 h
10. temperatureAfter the mixture was cooled to room temperature
11. filtrationthe mixture was filtered through paper
12. filtrationfilter
13. washthe cake was washed with isopropylether (200 mL)
14. customdried under reduced pressure at room temperature