Tetrahydrofuran → 3-Amino-5-chloro-6-[2-(2-hydroxy-ethoxy)-ethoxy]-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid cyclopropylamide
Reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:8][Si:9]([N-:10][Si:11]([CH3:12])([CH3:13])[CH3:14])([CH3:15])[CH3:16].[CH:18]1([NH:21][C:22](=[O:23])[c:24]2[c:25]([NH2:38])[c:26]3[c:27]([n:28][c:29]([S:34]([CH3:35])=[O:36])[c:30]([Cl:33])[c:31]3[CH3:32])[s:37]2)[CH2:19][CH2:20]1.[Li+:17].[OH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7]>>[O:1]([CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7])[c:29]1[n:28][c:27]2[c:26]([c:25]([NH2:38])[c:24]([C:22]([NH:21][CH:18]3[CH2:19][CH2:20]3)=[O:23])[s:37]2)[c:31]([CH3:32])[c:30]1[Cl:33]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-e2b1662ddbb14db1ac3dec93fd8d174d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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