Methane → 3-(2-{4-[5-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-propylpyridin-2-yl]piperazin-1-yl}ethyl)-5-[4-(1-methylethoxy)phenyl]-5-methylimidazolidine-2,4-dione
Reaction equation
[C:61].[CH3:55][CH2:56][O:57][C:58](=[O:59])[CH3:60].[F:1][C:2]([C:3]([C:4]([F:5])([F:6])[F:7])([O:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([O:14][CH3:15])[cH:16][cH:17]1)[c:18]1[c:19]([CH2:50][CH2:51][CH3:52])[cH:20][c:21]([N:24]2[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][N:32]3[C:33](=[O:49])[NH:34][C:35]([CH3:38])([c:39]4[cH:40][cH:41][c:42]([O:45][CH:46]([CH3:47])[CH3:48])[cH:43][cH:44]4)[C:36]3=[O:37])[CH2:28][CH2:29]2)[n:22][cH:23]1)([F:53])[F:54].[Pd:62]>>[F:1][C:2]([C:3]([C:4]([F:5])([F:6])[F:7])([OH:8])[c:18]1[c:19]([CH2:50][CH2:51][CH3:52])[cH:20][c:21]([N:24]2[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][N:32]3[C:33](=[O:49])[NH:34][C:35]([CH3:38])([c:39]4[cH:40][cH:41][c:42]([O:45][CH:46]([CH3:47])[CH3:48])[cH:43][cH:44]4)[C:36]3=[O:37])[CH2:28][CH2:29]2)[n:22][cH:23]1)([F:53])[F:54]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-8616ff101fdf41b4a90f87f05b8591da
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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