Hydrochloric Acid → HCID 28354564, compound

HRID 1744057Notes

Reaction equation

HRID 1744057 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[Li+].[OH-].Cl>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:9]([OH:11])=[O:10])=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86594553HCID 86594553, compound

Product 1

HCID 28354564HCID 28354564, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To methyl (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoate (2.198 g, 7.0 mmol) in MeOH (30 mL) was added an aqueous solution of LiOH (2 M, 17.5 mL, 35 mmol) and the reaction was stirred overnight. The reaction was neutralized with aqueous 10% HCl (pH of 6–7) and the product crystallized out of solution and was filtered and dried in vacuo to afford (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoic acid.

Workup

  1. customthe product crystallized out of solution
  2. filtrationwas filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-27630d94e7314f20af4009d83d8fa504
Source dataset
uspto-grants-2006_03
Patent number
US07012075B2

Reaction notes

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