反应详情

温度

60 °C

N-[3-Cyano-4-(piperazin-1-yl)phenyl]-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide (2 g), 2-dimethylaminoethyl chloride hydrochloride (0.85 g) and potassium carbonate (0.8 g) were added to dimethylformamide (20 ml) and the mixture was stirred at 60° C. for 3 h. The reaction mixture was added into water and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated under reduced pressure. Ethanol was added to the residue to allow crystallization. The crystals were recrystallized from hydrous ethanol to give the title compound (0.3 g), melting point: 185° C.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. customthe solvent was evaporated under reduced pressure
4. additionEthanol was added to the residue
5. customcrystallization
6. customThe crystals were recrystallized from hydrous ethanol