反应详情

温度

0 °C

A 500 mL round bottom flask equipped with a stirring bar was charged with 67.2 g (0.60 mol) 3-cyclohexene-1-methanol, and 170 mL of pyridine. The mixture was cooled to 0° C. Tosyl chloride (120.8 g, 0.63 mol) was slowly added to above mixture at 0–5° C. The reaction was carried out for 3 hrs. The reaction mixture was poured into 1.2 L of HCl solution (1 M), extracted with chloroform (3×200 mL), washed with water (3×200 mL), dried with sodium sulfate. The solvent was evaporated and the residue distilled under vacuum to give a tosylate.

1. customA 500 mL round bottom flask equipped with a stirring bar
2. extractionextracted with chloroform (3×200 mL)
3. washwashed with water (3×200 mL)
4. dry with materialdried with sodium sulfate
5. customThe solvent was evaporated
6. distillationthe residue distilled under vacuum