Di-tert-butyl dicarbonate → HCID 178484843, compound

HRID 1744819Notes

Reaction equation

HRID 1744819 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH2:8])[CH2:4][CH2:3]1.[C:9](OC(OC(C)(C)C)=O)(OC(C)(C)C)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>[OH-].[Na+].C1COCC1>[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][CH3:9])[CH2:4][CH2:3]1

Participants

6

Reactant 3

HCID 90495Di-tert-butyl dicarbonateHCID 21226445Aluminium lithium hydrideHCID 178511715HCID 178511715, compound

Product 1

HCID 178484843HCID 178484843, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14798Sodium HydroxideSolvent

Procedure

The title compound was prepared from (trans)-(4-hydroxy-cyclohexyl)-amine by reaction with di-tert.-butyl dicarbonate in aqueous sodium hydroxide under standard conditions and subsequent reduction with lithium aluminum hydride in THF under standard conditions.

Sources & evidence

ORD record
ord-ca5c9d42771d4d37ad8dd1a8eee67464
Source dataset
uspto-grants-2006_03
Patent number
US07019001B2

Reaction notes

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