4-chloro-6,7-dihydro-5h-cyclopenta[d]pyrimidin-2-amine → HCID 12290586, compound

HRID 1744940Notes

Reaction equation

HRID 1744940 reaction equation
Cl[C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([NH2:11])[N:3]=1.[O-:12][CH2:13][CH3:14].[Na+]>C1(C)C(C)=CC=CC=1.C(O)C>[CH2:13]([O:12][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([NH2:11])[N:3]=1)[CH3:14]

Participants

5

Reactant 2

HCID 2303324-chloro-6,7-dihydro-5h-cyclopenta[d]pyrimidin-2-amineHCID 2723922Sodium ethoxide

Product 1

HCID 12290586HCID 12290586, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 7237O-XyleneSolvent

Procedure

5.1 grams of 4-chloro-6,7-dihydro-5H-cyclopentapyrimidin-2-ylamine was dissolved in 200 ml xylene and 30 ml absolute ethanol. Then 6.8 gram for sodium ethoxide was added and the mixture was refluxed for 3 hours. Then the solvent was removed in vacuo and 100 ml water was added to the residue. Filter and wash the cake with water (50 ml). The solid was further vacuumed to dry for several hours. The desired product weighed 5.3 gram (98% yield). Mp: 133.8˜134.9° C.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. customThen the solvent was removed in vacuo and 100 ml water
  3. additionwas added to the residue
  4. filtrationFilter
  5. washwash the cake with water (50 ml)
  6. customto dry for several hours

Sources & evidence

ORD record
ord-6c0137a782624959b65be11e62306e86
Source dataset
uspto-grants-2006_03
Patent number
US07018997B2

Reaction notes

Loading…