Potassium Carbonate → HCID 11172083, compound

HRID 1744953Notes

Reaction equation

HRID 1744953 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]3[CH:11]=[C:10]([C:12](OCC)=[O:13])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1.[Li+].[BH4-].C([O-])([O-])=O.[K+].[K+]>C1COCC1>[F:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]3[CH:11]=[C:10]([CH2:12][OH:13])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 396585HCID 396585, compoundHCID 4148881Lithium borohydride

Product 1

HCID 11172083HCID 11172083, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Fluoro-imidazo[2,1-b]-benzthiazole-2-methanol was prepared starting from Ethyl 7-fluoro-imidazo[2,1-b]-benzthiazole-2-carboxylate (2.64 g, 0.01 mol) and LiBH4 (50 mg) in THF at refluxing temperature for 2 hrs. at the end, reaction mixture was quenched with ice cold water and acidified with 10 N. HCl. Reaction mixture was stirred for 1 hr and nuetralized with K2CO3. The separated residue was extracted with chloroform:methanol (3:1) and dried over anhydrous MgSO4. It was filtered and concentrated. The crude reaction mixture was found to be pure and taken to next step with out any purification. Yeild: 1.5 g (68%) Semi solid; M+H 223.

Workup

  1. temperatureat refluxing temperature for 2 hrs
  2. customat the end, reaction mixture
  3. customwas quenched with ice cold water
  4. customReaction mixture
  5. extractionThe separated residue was extracted with chloroform:methanol (3:1)
  6. dry with materialdried over anhydrous MgSO4
  7. filtrationIt was filtered
  8. concentrationconcentrated
  9. customThe crude reaction mixture
  10. customtaken to next step with out any purification

Sources & evidence

ORD record
ord-0447dff528ee4006b28c9e0145becc26
Source dataset
uspto-grants-2006_03
Patent number
US07018997B2

Reaction notes

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