N-Methylbenzylamine → HCID 131725441, compound

HRID 1745060Notes

Reaction equation

HRID 1745060 reaction equation
[CH2:1]([O:8][N:9]=[C:10]1[CH2:14][N:13]([C:15]([O:17]C(C)(C)C)=O)[C@H:12]([C:22]([OH:24])=O)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]1([CH:31]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)C(Cl)=O)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[CH2:41]([NH:48][CH3:49])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[CH2:41]([N:48]([CH3:49])[C:22]([C@@H:12]1[CH2:11][C:10](=[N:9][O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:14][N:13]1[C:15](=[O:17])[CH:31]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:24])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1

Participants

4

Reactant 3

HCID 7669N-MethylbenzylamineHCID 746372,2-Diphenylacetyl chlorideHCID 131725420(2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725441HCID 131725441, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and N-benzyl-N-methylamine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z=532.4.

Sources & evidence

ORD record
ord-806a4ba6abaa494bb07790204b475678
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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