Piperidine → HCID 131725558, compound

HRID 1745222Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[C:27]1([CH:33]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)C(Cl)=O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[NH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1>>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][O:14][N:13]=[C:11]2[CH2:10][C@@H:9]([C:24]([N:43]3[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]3)=[O:26])[N:8]([C:6](=[O:7])[CH:33]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH2:12]2)=[CH:21][CH:20]=1

Participants

Reactant 3

HCID 8082Piperidine

HCID 746372,2-Diphenylacetyl chloride

HCID 58714542HCID 58714542, compound

Product 1

HCID 131725558HCID 131725558, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and piperidine the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z=526.4.

Sources & evidence

ORD record: ord-4189aaba0e584c8ebb94da1ae6117417
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07018988B2

Reaction notes

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