3-Bromopyridine → (2-Nitro-4-pyridin-3-yl-phenyl)-carbamic acid tert.-butyl ester

HRID 1745462Notes

Reaction equation

HRID 1745462 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].B1(B2OC(C)(C)C(C)(C)O2)OC(C)(C)C(C)(C)O1.Br[C:38]1[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:38]2[CH:39]=[N:40][CH:41]=[CH:42][CH:43]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 122863-BromopyridineHCID 2733548Bis(pinacolato)diboraneHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

Product 1

HCID 69592765(2-Nitro-4-pyridin-3-yl-phenyl)-carbamic acid tert.-butyl ester

Procedure

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1), bis(pinacolato)diboron and 3-bromopyridine according to the general procedure C. Obtained as a yellow solid (587 mg).

Sources & evidence

ORD record
ord-cfc8189afb9f429d8eddf1e685878227
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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