Triethylamine → HCID 54189546, compound

HRID 1745541Notes

Reaction equation

HRID 1745541 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](Cl)=[O:8].[K+].[C:11]([O:17][CH2:18][CH3:19])(=[O:16])[CH2:12]C([O-])=O.CCN(CC)CC.[Mg+2].[Cl-].[Cl-]>CC#N>[CH2:18]([O:17][C:11](=[O:16])[CH2:12][C:7]([C:3]1[S:4][CH:5]=[CH:6][C:2]=1[Cl:1])=[O:8])[CH3:19]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 3446434Potassium ethyl malonateHCID 5360315Magnesium Chloride

Product 1

HCID 54189546HCID 54189546, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 3-chloro-2-thiophenecarbonyl chloride [CAS-No. 86427-02-3] by reaction with ethyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a brown oil (6.84 g).

Sources & evidence

ORD record
ord-d559bbe00a664b9c870cdee7218b74c5
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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