Trifluoroacetic acid → HCID 22224949, compound

HRID 1745682Notes

Reaction equation

HRID 1745682 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C)[CH:15]=2)=[CH:10][C:9]=1[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=1)=O)(C)(C)C.[C:36](O)(C(F)(F)F)=O>C(Cl)Cl>[O:34]=[C:22]1[CH2:23][C:24]([C:26]2[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=2)[C:32]#[N:33])=[N:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:15]=[C:16]([CH3:36])[CH:17]=[CH:18][CH:19]=3)=[CH:10][C:9]=2[NH:21]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588004{3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-3'-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Product 1

HCID 22224949HCID 22224949, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-3′-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K15) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow powder (145 mg).

Sources & evidence

ORD record
ord-bf94704a7f704b128b138092cad7b1be
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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