Trifluoroacetic acid → HCID 22224632, compound

HRID 1745733Notes

Reaction equation

HRID 1745733 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH:21][C:22](=[O:32])[CH2:23][C:24]([C:26]1[S:27][CH:28]=[CH:29][C:30]=1[Cl:31])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:31][C:30]1[CH:29]=[CH:28][S:27][C:26]=1[C:24]1[CH2:23][C:22](=[O:32])[NH:21][C:9]2[CH:10]=[C:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[CH:12]=[CH:13][C:8]=2[N:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588046HCID 86588046, compound

Product 1

HCID 22224632HCID 22224632, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-chloro-thiophen-2-yl)-3-oxo-propionylamino]-4′-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K61) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (232 mg).

Sources & evidence

ORD record
ord-1026bef08ac7438286a1914b350d6545
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

Loading…