Potassium Carbonate → HCID 69040835, compound

HRID 1746104Notes

Reaction equation

HRID 1746104 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]1[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][C:18]=1[F:27]>CN(C=O)C>[F:27][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([C:23]([F:24])([F:25])[F:26])[C:17]=1[CH2:16][N:6]1[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:8]=[N:7]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 163764-nitro-1H-pyrazoleHCID 27375732-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

Product 1

HCID 69040835HCID 69040835, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

4-Nitropyrazole (Aldrich; 4.974 g, 44.0 mmol) was dissolved in DMF (100 ml) and potassium carbonate (9.12 g, 66.0 mmol) was added. The reaction mixture was allowed to stir at ambient temperature under nitrogen for approximately 5 minutes. 2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (Aldrich; 11.31 g, 44.0 mmol) in DMF (25 ml) was then added over a period of approximately 5 minutes and the reaction was left to stir overnight.

Workup

  1. waitthe reaction was left
  2. stirringto stir overnight

Sources & evidence

ORD record
ord-8834dfa94bbe422c84f28088a45886db
Source dataset
uspto-grants-2015_10
Patent number
US09149462B2

Reaction notes

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